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A bad diet - in a study feeding mice a western-style diet, impaired hepatic glutathione synthesis and lower plasma levels were found

One of these studies demonstrated a 1.7-fold higher recovery of toxic metabolites in those with Gilberts syndrome compared to controls [33], although a larger study only found a higher rate of recovery of toxic metabolites in those patients stratified by having the lowest UGT activity [28]

Yang, J., Luo, J., Tian, X., Zhao, Y., Li, Y., & Wu, X

Pathological role for exocytotic glutamate release from astrocytes in hepatic encephalopathy

But more importantly it is incredibly effective and stable

As much as 75% of L-carnitine comes from the dietary intake of red meat and dairy products ( Table 2 ), whereas only 25% is generated by endogenous biosynthesis