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Abstract The thioredoxin system, comprising thioredoxin (Trx) and thioredoxin reductase (TrxR), is a central regulator of cellular redox homeostasis and plays essential roles in normal brain physiology and redox signaling

In NSCLC, carbon monoxide (CO) directly triggers ferroptosis through the ROS/GSK3/GPX4 axis, resulting in the accumulation of LOOH (91)

Similarly, BH4 is essential for melatonin , which is synthesized from serotonin

However, medical supervision helps ensure optimal dosing, appropriate monitoring, and safety when using multiple compounds simultaneously

2004;134:2072S2080S