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The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology

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S2 harbors the fusion peptide (FP) which anchors to target membranes and mediates membrane fusion by connecting with lipid bilayers of the host cell, while S1 plays a key role in bringing viral and cellular membranes into close proximity to permit lipid bilayer fusion [10]

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