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Gastroenterology 163, 495506.e8

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Moreover, the absence of AIMP1 in bone marrow-derived dendritic cells (BMDCs) reduced downstream Th1 polarization of T cells by impairing p38 MAPK signaling, which significantly weakened BMDC vaccine-mediated protection against melanoma 64

some trials have demonstrated positive effects (Imamura et al., 2017), while others revealed either detrimental effects (Lonn et al., 2005) or no effects at all (van der Made et al., 2015)