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This process of retrograde signaling or mitochondria talking to the nucleus is a newly recognized aspect of cell biology, and MOTS-c is one of the best examples we know of

it protects every cell, tissue, and organ from toxins, intercepts and neutralizes toxins in the gut, and is involved in DNA repair

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If the force was maintained for the required 3 seconds, a green tick indicated successful task performance during a single trial (see Supplementary Figure 3B)

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Astrocytes are implicated in various CNS disorders, e.g., Alzheimer's disease (Parpura et al., 2012) and demyelinating disorders such as neuromyelitis optica and MS (Nair et al., 2008