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(38683591) However, in highly complex patients who are at risk of over-sedation, PRN short-acting opioids may be safer

This shift will undoubtedly impact profit margins, as shown below

doi: 10.1002/mnfr.201801045 115

Footnotes Declaration of Conflicting Interests: The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Dr Sciubba is a consultant for Medtronic, Depuy-Synthes, Stryker, Nuvasive, and K2M