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The effect of acylcarnitine on insulin sensitivity is also related to the saturation of acylcarnitine, with myotubes incubated with C16-carnitine exhibiting reduced insulin sensitization, whereas the accumulation of oleoylcarnitine (C18:1-carnitine) and linoleoylcarnitine (C18:2-carnitine) increases insulin sensitization [77]

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PMC 122369

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This leads to a reduction in TCA cycle gene expression and oxygen consumption as well as an increase in lactate production and cell proliferation 89

The functional characterization of CT2 is still at its infancy, but its peculiar tissue distribution suggests that this transporter is involved in maintaining the epidydimal gradient of carnitine that plays as osmolyte and FAO cofactor