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Since cell membranes are negatively charged, peptide drugs can efficiently penetrate membranes when their overall charge is neutral or positive 42

This shift can affect barrier function, inflammatory balance, and gutbrain signaling.*1-3

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Moreover, internal triggers like excess sugar, processed foods, trans fats, and hormonal dysregulation (like insulin resistance or PCOS) can worsen acne and delay wound healing

Heres how I explain it to patients: after an injury, your body sends repair crews to the damage site to create new blood vessels, collagen-producing cells, anti-inflammatory signals