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Their use should be individualised, considering patient-specific profiles and other potential risks, in line with a precision psychiatry approach

When taken orally, metformin is concentrated in the intestine at levels up to 300 times greater than in the blood, significantly influencing the composition and metabolism of the gut microbiota [16]

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Laut Fachinformation ist Brodalumab bei aktivem M

In this sense celecoxib showed to be a safe and a highly effective therapeutical option in resistant bipolar depression, reducing anxiety and accelerating treatment response [335], in a similar way to aspirin [336]