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In particular, the incredibly high throughput of H 2 O 2 molecules from outside the enzyme deep into its active-site interior, and water/oxygen egress post reaction, would all seem to militate against the notion of an essentially random, iterative, molecule-by-molecule H 2 O 2 disproportionation reaction mechanism

Consistent with these predictions, the most significant differences in gene expression were seen for genes (e.g., N-cadherin (CDH2), versican (VCAN), L6 cell surface antigen (TM4SF1) and layilin (LAYN)) associated with cell invasion, migration, metastasis and the epithelialmesenchymal transition

152 Optimal nerve and muscle function depend on proper membrane potential (polarity)

doi: 10.1097/MD.0000000000039142 101 KontoghiorghesGJ

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We hypothesized that high 15LO1, PEBP1, and GPX4 activity drives abnormal asthmatic redox biology, evidenced by lower bronchoalveolar lavage (BAL) fluid and intraepithelial cell GSH:oxidized GSH (GSSG) ratios, to enhance type 2 (T2) inflammatory responses