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Arch Toxicol 2015;89:1939 [DOI] [PubMed] [Google Scholar] 19.Chia AJ, Goldring CE, Kitteringham NR, Wong SQ, Morgan P, Park BK.Differential effect of covalent protein modification and glutathione depletion on the transcriptional response of Nrf2 and NF-kappaB

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Most people tolerate them well, with minimal side effects

Notably, RNA is particularly susceptible to this chemical damage leading to translational defects and impaired protein synthesis, particularly through the formation of 8-oxo-G lesions in ribosomal and messenger RNA

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