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The discovery of GPCRs constitutive activity has had a profound impact both in the pharmacological study of these receptors and in an increased understanding of the molecular mechanisms of certain diseases with which it is associated

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J Allergy Clin Immunol 118 : 12181225 Fitzpatrick AM, Teague WG, Holguin F, Yeh M, Brown LA, Severe Asthma Research Program 2009 Airway glutathione homeostasis is altered in children with severe asthma: evidence for oxidant stress

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