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Comment: One commenter pointed to the significant methodological changes to individual measures finalized in the Fiscal Year (FY) 2026 Inpatient Prospective Payment System (IPPS) final rule (90 FR 36997 through 37027), such as the use of Medicare Advantage (MA) data, changes in risk adjustment models, removal of COVID-19 vaccination measures, and re-baselining of HAI measures, and urged CMS to delay implementation of Stage 2 for a year after updated data is publicly available and after conducting a comprehensive analysis of the combined effects before finalizing further penalties

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Route of administration to bypass the BBB : Intrathecal administration of drugs enables the delivery of therapeutic products to the cerebrospinal fluid, which can be distributed throughout the ventricular system and eventually enter the brain parenchyma

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