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Modifications by NS of mediators and signaling pathways associated with antioxidative and anti-inflammatory systems were inconsistent

Stem cell-based and exosome-based therapies Beyond pharmacological agents, biological therapies such as stem cells and exosomes represent a transformative frontier in ICH management 37

In high-fat diet (HFD)-induced mouse models, DNA damage activates PARP-1, which stimulates the activation of NLR family pyrin domain containing 3 (NLRP3) and its downstream signaling proteins (57)

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doi: 10.1038/s41538-023-00190-6 77 TominariTMatsumotoCTanakaYShimizuKTakatoyaMSugasakiMet al

Detailed analysis of inflammatory biomarkers and cytokines also improved, and there were no treatment-related adverse events