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Moreover, several risk factors were linked to the pathophysiology of intestinal dysbiosis, antibiotic usage was shown to both transiently and permanently alter the composition of the gut microbiome (78, 79)

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Data are expressed as median with interquartile range for ( f )

This approach enhances treatment efficacy, overcomes resistance, and reduces required doses, minimizing side effects

[,] Advance cirrhosis or acute liver failure induces marked renal dysfunction characterized by reducing renal blood flow and glomerular filtration rate (GFR), and this has been referred to as hepatorenal syndrome (HRS). [,] Conventionally, HRS occurs in two different clinical patterns, type 1 HRS (HRS-1, characterized by abrupt impairment of renal function that often occurs because of a precipitating event) and type 2 HRS (HRS-2, a moderate and stable or slowly progressive renal dysfunction often occurs without an obvious precipitant, and it is associated with refractory ascites)

Notably, SLC27A5 negatively correlates with GSR, and genetic or pharmacological inhibition of GSR strengthens the efficacy of sorafenib through GSH depletion and the accumulation of lipid peroxide products in SLC27A5-knockout and sorafenib-resistant HCC cells