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It is prohibited in sport under WADAs S0 (Non-approved Substances)

Lipotropic injections are generally not recommended during pregnancy or breastfeeding, for people with a known allergy to any component of the formulation (including B12/cobalt), for those with certain kidney or liver conditions, or for those with certain medical conditions

It is connected to the arrector pili muscle, which responds to stimuli such as cold or fear, causing it to contract, which in turn leads to hair standing up

doi: 10.1007/s10637-009-9311-z

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Weight loss typically accelerates during this period, with most researchers reporting 4-8% body weight reduction by week 12