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Participants were all outpatients and for initial enrollment were required to have a score 18 on the 17-item HAM-D and have a history of inadequate response to two or more antidepressants, specifically listed in Section A: Recognized Antidepressants of the Maudsley Treatment Inventory 53 , prescribed at a minimum effective dose for at least 6 weeks, or at least one antidepressant prescribed at the minimum effective dose for at least 6 weeks and a course of evidence-based psychotherapy

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doi: 10.3945/ajcn.110.003483 254 SestiliP.FimognariC

10.3389/fneur.2017.00101 Summary Keywords extracellular matrix reorganisation, basal lamina, melatonin receptors, Schwann cells, circadian rhythm, peripheral nerve injury Citation Klymenko A and Lutz D (2022) Melatonin signalling in Schwann cells during neuroregeneration

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BPC-157 in particular has been studied extensively in animal models and small human series