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DEM has been reported to produce a non-linear response to glutathione depletion, with a minor glutathione loss induced by DEM at 10100 M increasing lifespan via hormesis, but a major glutathione loss induced by DEM 1 mM shortening lifespan (Urban et al., 2017)

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[79] All the PPIs except tenatoprazole are rapidly metabolized in the liver by CYP enzymes (mostly by CYP2C19 and 3A4)

Age-related macular degeneration Age-related macular degeneration (AMD) is the primary cause of blindness among older adults in industrialized countries

Crit Care Clin (2009) 25:16584

More importantly, after long-term CCl4 treatment in Nrf2 gene knockout mice, liver fibrosis was severely intensified, and inflammation increased (Xu et al., 2008)