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USA 113 , 71247129 (2016)

Gaspoz, Genve (Mdecine interne gnrale)

The initial characterization and cloning of the HIF1A and ARNT (which encodes HIF1) cDNAs, showing the O 2 -labile nature of the HIF1 subunit as a mechanism that regulates the expression of hypoxia-induced target genes

reuteri further exemplifies strain-specific synergy with ICIs: it produces the Trp metabolite ILA, which expands IFN- + Th1/TC1 cells and enhances ICI-mediated tumor regression in preclinical models (113)

[DOI] [PMC free article] [PubMed] [Google Scholar] Thomas T, Stefanoni D, Dzieciatkowska M

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