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10.1126/science.aaw6421 Science 45 GuoR.GewurzB

phosphomannose isomerase (PMI)

Given the low therapeutic doses (0.10.5 mg/kg), rapid onset of action, sustained efficacy, and the feasibility of repeated administration without triggering hepatotoxicity, inflammation, or an immune response, hMUT mRNA-based therapy represents a versatile and promising option for MMA treatment [296]

Needed studies for Chemical Defense clinical indication including pharmacokinetics, safety, efficacy, pregnancy, breastfeeding, and review panel recommendations No data available at this time