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Similarly, the phase IIa PBT2 trial demonstrated acceptable safety and modest biomarker modulation without significant clinical efficacy (Ayton et al., 2025)

The gating strategy is described in Supplemental Figure 1

Metabolite extraction of the area surrounding cerebral infarction in mice Tissue metabolites were extracted with some modifications of a previously described method [39]

The impact of melatonin on long-term potentiation is contingent upon concentration levels

A body of literature has demonstrated that inflammatory cytokines activate many of the molecular pathways involved in skeletal muscle wasting, leading to an imbalance between protein synthesis and degradation [4,5]

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