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References Wessells H, et al

The difference between melanosis and melanoma is that the former is caused by noncancerous cells that produce excessive pigment in the skin, while melanoma is caused by cancerous cells that produce excessive pigment in the skin

If this is true, then it is likely that either the upregulated process of melanin biosynthesis, the increased amount of melanin in the melanocytes, or both, occurring in the fields of benign oral melanin hyperpigmentation, constitute risk factors for transformation into oral mucosal melanomata

Topical MTII Therapy Suppresses Melanoma Through PTEN Upregulation and Cyclooxygenase II Inhibition