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CRJ: data curation, writing-original draft preparation

doi: 10.1186/s13073-017-0407-3 42 DuffyDJKrsticAHalaszMSchwarzlTFeyDIljinKet al

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Adverse Reactions in Patients for Weight Reduction and Long-Term Maintenance Pool of Placebo-Controlled Weight Reduction Trials in Adults with Obesity or Overweight, with or without Type 2 Diabetes (Study 1 and Study 2) ZEPBOUND was evaluated for safety in a pool of two randomized, double-blind, placebo-controlled trials that included 2,519 adult patients with obesity or overweight treated with ZEPBOUND for up to 72 weeks and a 4-week off drug follow-up period (Study 1 and Study 2) [see Clinical Studies (14.1)]

In addition, decreased live fetal weight occurred in high dose rats, but not in rabbits

Reduction in the activity of this enzyme decreases the conversion of substrates into fatty acids, thereby shifting cellular metabolism toward lipid mobilization rather than storage [1]