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The role of MiRNA in polycystic ovary syndrome (PCOS)

The increase of intracellular ROS is believed to correlate with the activation of nuclear factor (NF)-kappa B, a transcription activator linked to the elaboration of several cytokines (Figure 6)

Protein misfolding and failure of clearance systems, including the autophagy-lysosome and ubiquitin-proteasome pathways, further compromise the cellular environment and lead to toxic intracellular accumulations [31, 32]

The change from uncompetitive to non-competitive mechanism induced by chemical modifications of the inhibitors is not rare in drug design studies 48,49,50