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Nonetheless, high Cu levels alter the localization of ATP7B to lysosomes, leading to the release of Cu via vesicular transport (Yu et al., 2021)

5 Conclusion Several evidence suggest that D-lactate may enhance glycolytic activity in PMNs, FLS, and macrophages, disrupt cellular function, and that can induce an inflammatory response

The use of epi-drugs alone, or in combination with chemotherapy or immunotherapy, has shown compelling outcomes, including augmentation of anti-tumoral effects, overcoming drug resistance, and activation of host immune response