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Although generally safe, injections should be used with caution in people with a history of allergic reactions to cobalamin or in people with Leber's disease (hereditary optic neuropathy), as B12 may worsen the condition

However, some compounding pharmacies may offer it as a research chemical

Microneedling works by creating controlled micro-injuries in the skin, stimulating collagen and elastin production to improve texture, tone, and overall skin quality

Liu SQ, Tian Q, Hedrick JL, Po Hui JH, Ee PL, Yang YY

The addenda relating to the ASC payment system are available at

Regarding the form of vitamin B12 used, cyanocobalamin was the most common (n = 14), followed by methylcobalamin (n = 6), hydroxocobalamin (n = 4), and combinations including adenosylcobalamin in isolated cases