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Nicotine, alongside many different synthetic substances, connects itself to the tar inside the smoke and is consumed by the lungs when the smoke contacts tissue cells

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Smoked and intravenous cocaine in humans: acute tolerance, cardiovascular and subjective effects

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Compared to baseline smoking rates of 21 cigarettes per day, participants who received nicotine ecigarettes reduced their daily cigarette consumption by 13 cigarettes per day compared to 11 among participants receiving non-nicotine e-cigarettes and seven among those receiving counseling alone