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Tian, D., Zhu, M., Li, J., Ma, Y

Henry Fung, who runs the CAR-T program at Fox Chase Cancer Center in Philadelphia

However, oxidative stress or GSH depletion causes TXNIP to dissociate from TXN and instead bind to NLRP3, inducing conformational activation and promoting inflammasome assembly 53,54

Other nonenzymatic antioxidant systems, such as vitamins C and E, may also display selective, context-dependent effects rather than exerting global protein reduction, suggesting that a deeper understanding of antioxidant specificity is critical for developing targeted therapies (61, 62)

First, their regulation is very similar

82:10761080 Arndt S, Baeza-Garza CD, Logan A, Rosa T, Wedmann R, Prime TA, Martin JL, Saeb-Parsy K, Krieg T, Filipovic MR, Hartley RC, Murphy MP (2017) Assessment of H 2 S in vivo using the newly developed mitochondria-targeted mass spectrometry probe Mitoa