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In particular, mTORC2 serves as a key regulator by controlling the activity of the glutamine-glutamate antiporter (xCT)

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*Correspondence: Hitoshi Ando, [email protected] This article was submitted to Pharmacology of Anti-Cancer Drugs, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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BDNF promotes the regeneration and sprouting of axons in the reticulospinal, rubrospinal, and vestibulospinal tracts

Pro-inflammatory cytokines similarly link autophagy to apoptosis and have been shown to be associated with neuropathic pain (138), This phenomenon suggests that we may be able to further explore whether there are pro-inflammatory cytokine-related drugs to treat neuropathic pain in DPN patients by improving the apoptosis and autophagy link