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2) The study performed by the research team of Mass et al investigated the effects of AcSDKP on hematologic toxicity and bone marrow recovery following doxorubicin (DOX) treatment in BALB/c mice

Ambrosy, A

others can gain novel biological activities and thereby contribute to the various pathophysiological processes

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Curcumin regulates a diversity of molecular targets, prominently inhibiting transcription factors like NF-$\kappa$B and downregulating inflammatory cytokines such as Tumor Necrosis Factor (TNF), Interleukin 1 (IL-1), and IL-6.21 Resveratrol, a phenolic compound, is also well-known for suppressing the NF-$\kappa$B signaling pathway, which contributes to its anti-inflammatory and antioxidant properties.22 The efficacy of compounds that modulate both Nrf2 (upregulation) and NF-kappaB(downregulation)such as Curcumin or ursolic acid found in apple productsstems from the fundamental crosstalk between these two pathways, as Nrf2 deficiency can lead to elevated NF-kappaB expression

Discussion In this study, we explored connections among Cys availability, hydropersulfide levels, free radical levels, LPO and ferroptosis sensitivity