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(6) Studies have documented that NNMT is highly expressed in white adipose tissue and that its expression correlates with obesity in both humans and animal models

et al., 2019), Yuanhuadine (Bach et al., 2018), and CC-410 (Roberti et al., 2023)

Although 5-Amino-1MQ is still considered an emerging longevity compound, its ability to inhibit NNMT positions it as one of the most promising tools for preserving NAD+ and supporting mitochondrial health, especially when combined with NAD+ therapy

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Restoring NAD+ levels in aging and metabolic stress models improved glucose tolerance, mitochondrial function, and overall health [1]