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Funding Statement This work received financial support under the framework Projeto VIIAFOODPlataforma de Valorizao, Industrializao e Inovao Comercial para o AgroAlimentar (C644929456-00000040), financed by financiado pelo PRRPlano de Recuperao e Resilincia and by European funds NextGeneration EU

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In this Review, we discuss the progress made in the development of such modulators for the treatment of depression, and examine recent preclinical and translational studies that have investigated the mechanisms of action of glutamate-targeting antidepressants