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Potential therapeutic strategies include inhibiting neutrophil NET formation, regulating neutrophil apoptosis pathways, intervening in TLR9-mediated endoplasmic reticulum stress, and targeting gut microbiota and their metabolites

IUBMB Life 63, 5461

References GBD 2017 Risk Factor Collaborators Global, regional, and national comparative risk assessment of 84 behavioural environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 19902017: a systematic analysis for the Global Burden of Disease Study 2017

To address these issues, researchers are exploring advanced drug delivery methods and better quality control with modern analytical tools

Keap1 degradation by autophagy for the maintenance of redox homeostasis

Have a history of long-term antibiotic use, which can reduce the ability of the stomach to absorb and use vitamin B12