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370,371 Alignment between the circadian clock and environmental and physiologic cyclesor circadian synchronycan be disturbed by a range of common behaviors and conditions, including shiftwork, late-night social or other activities, and travel through time zones

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LAG3 is an important inhibitory immune checkpoint that, by binding to MHC II molecules, suppresses T cell activation and proliferation ( + T cells into the tumor microenvironment, but also promotes T cell exhaustion by downregulating the secretion of key cytokines, such as IFN- ( Using the TIDE algorithm, our study predicted immunotherapy outcomes and found that patients in the high-risk group had higher overall TIDE and immune exclusion scores, with significantly lower response and benefit rates compared to the low-risk group