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To increase the movement efficiency and therapeutic value of NPs in TME, the biological barrierssuch as abnormal vasculature, rigid ECM, acidic pH, hypoxia, irregular enzyme levels, changed metabolic pathway, and immunosuppressionmust be addressed [101]

[PubMed] Ohashi H, Nishioka K, Nakajima S, Kim S, Suzuki R, Aizaki H, Fukasawa M, Kamisuki S, Sugawara F, Ohtani N, Muramatsu M, Wakita T, Watashi K (2018) The aryl hydrocarbon receptor-cytochrome P450 1A1 pathway controls lipid accumulation and enhances the permissiveness for hepatitis C virus assembly