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These limitations impact the strength of our understanding and underscore the pressing need for additional research to fill knowledge gaps and improve therapeutic strategies

Model validation was performed using Kaplan-Meier curves based on risk scores

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These alterations are associated with increased levels of THs binding protein levels, upregulation of DIO1 and 2 activities and downregulation of DIO3

Ultimately, these debates converge on a central translational question: is ROS itself a druggable target, as evidenced by the success of ROS-inducing chemo-immunotherapies [222,223,224,225] and nanomedicines [278, 291, 335], or is its true utility as a predictive biomarker for patient stratification [235, 236]