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Overexpression of TFEB leads to degradation of bulk autophagic substrates such as damaged mitochondria (Nezich et al., 2015), long-lived protein aggregates (Martini-Stoica et al., 2016), and lipid droplets (Settembre et al., 2013), indicating the crucial role of TFEB in organelle-specific autophagy, such as mitophagy and lipophagy (Settembre et al., 2013

These enzymes constitute the primary cellular defense against reactive oxygen species (ROS), and their expression declines with age in many tissue types

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Gouty D, Cai CC, Cai XY, Kasinath A, Kumar V, Alvandkouhi S, et al