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PMC 6853652

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10.1093/jnci/88.3-4.193 J

The gut microbiota-immune-brain axis: therapeutic implications

Mice lacking the clock activator Bmal1 in adipocytes ( Bmal1 knockout (KO)) displayed reduced mitochondrial OCR in response to pyruvate during the dark period (ZT14) compared with mice with an intact clock

Decreased abundance of non-parenchymal cells including Kupffer cells and stellate cells were seen in liver transcriptome analysis (Fig B)