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Interestingly, the same pathway may also be utilized during inflammatory responses, mediated by the tumor necrosis factor-alpha (TNF-)

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In aqueous solution, the equilibrium of acid dissociation can be written symbolically as: HA + H 2 O = A - +H 3 O + where HA is an acid that dissociates into A - , (known as the conjugate base of the acid) and a hydrogen ion which combines with a water molecule to make a hydronium ion