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In states of high iodine intake, increased hydrogen peroxide generation enhances oxidative stress within thyroid follicles, promoting antigen presentation and autoimmune activation ( From a mechanistic perspective, iodine status creates a U -shaped risk curve for neurological outcomes: insufficient intake undermines hormone synthesis and cognitive capacity, while excess fosters autoimmunity and inflammatory cascades ( 4.3 Mediterranean dietary pattern as a multi-pathway intervention The Mediterranean diet (MD) is not a single-nutrient strategy but a holistic dietary pattern that integrates multiple neuroprotective and thyroid-supportive components