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In mCRPC patients treated with PARP inhibition, ctDNA studies have identified a heterogeneous landscape of sub-clonal mutations in BRCA2 or PALB2 that are predicted to restore BRCA2 function in samples collected at the progression that were not present prior to treatment [122, 123]

Regulation of nutritional metabolism in transition dairy cows: Energy homeostasis and health in response to post-ruminal choline and methionine

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doi: 10.2147/JHC.S401639 68 XiaLXuXLiMZhangXCaoF

Proc Natl Acad Sci 105: 1922319228

Mutation in a cells DNA, usually in multiple locations, is the primary cause of cells becoming cancerous