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Although the reasons for this partitioning are only partially understood, these antioxidants are considered critical in both health and disease

10.1073/pnas.2003847117 17 DrewR.RodnickK.SettlesM.WacykJ.ChurchillE.PowellM.et al (2008)

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The pathologic cascade begins when renal damage activates cells, initiating the production of pro-inflammatory mediators and pro-fibrotic signaling pathways