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Key elements of the study design include data-independent acquisition (DIA)-proteomics analysis performed on synchronized ring-and trophozoite-stages of artemisinin resistant and sensitive parasites to evaluate differential protein expression, with a focus on PfK13 protein levels

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6.4 Summary of RCTs In the RIPENACTB trial, adjunct NAC treatment with 1,200 mg twice a day in hospitalized HIV/TB patients significantly reduced circulating lipid peroxidation (malondialdehyde (MDA) levels by approximately 40%50%) and increased antioxidant defenses, including glutathione (GSH, by approximately 30%40%), compared to baseline and the standard care group

doi: 10.1016/s1470-2045(23)00276-0

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