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Morphological alterations and induction of oxidative stress in glial cells caused by the branched-chain alpha-keto acids accumulating in maple syrup urine disease

J Plant Nutr 26:417430

High-dose oral B12 supplements are available over the counter for a few dollars per month, while injection visits typically involve copays, administration fees, and the time cost of repeated clinic appointments

the mechanisms exploited involve interventions on the RAS system [angiotensin-converting enzyme inhibitors (ACEIs), angiotensin II receptor blockers (ARBs)], vasodilation induced by direct vasodilators [calcium channel blockers (CCBs) such as dihydropyridine], the reduction in atrioventricular conduction (beta-blockers, CCBs such as phenylalkylamine, benzothiazepine), or diuretic actions capable of reducing electrolyte levels, particularly Na + (including loop diuretics, thiazides, and potassium sparing)

J.PedersenJ.HansenC

Again we see EGT trouncing vitamin E as a functional antioxidant, as vitamin E had virtually no effect on the cells' recovery