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Uniform manifold approximation and projection (UMAP) (64, 65) was used to transform the high-dimensional patient data, encompassing demographic information, symptoms, and comorbidities into a two-dimensional space

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For REU scoring system, lesion severity at each site will be assessed by scoring reticular/hyperkeratotic, erosive/erythematous, and ulcerative lesions using specific criteria: Reticular/hyperkeratotic changes will be rated as 0 (absence of white striations) or 1 (presence of white striations or keratotic papules)

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