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Vitamin B12 is a water-soluble vitamin that supports several vital processes in the body

Acknowledgments The authors thank the Interdisciplinary Graduate Program in the Biological and Biomedical Sciences and the Quantitative and Chemical Biology Program at the Vanderbilt University School of Medicine

In such cases, thiamine replacement should be initiated promptly and parenterally where indicated without waiting for laboratory confirmation , as deficiency can cause peripheral neuropathy and, in severe cases, Wernicke's encephalopathy, a neurological emergency