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The Potential Molecular and Cellular Mechanism of Flavonoids for Iron Overload Based on the previous research results, we summarized the underlying mechanisms of flavonoids for treating iron overload according to the following three mechanisms: amelioration of iron status by various proteins and pathways, chelation of iron to reduce iron deposition, and resistance to oxidation to reduce iron overload-induced oxidative damage (Figure 3A)

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free radical scavenging activity, suppression of intracellular calcium influx, blockage of Na + channel activation, reduction of intracranial pressure, tissue edema, and inflammation ( DMSO is a powerful free radical scavenger and its utilization in a condition of oxidative stress may prevent the accumulation of free radicals that consumed the enzymatic antioxidants and reduce their levels ( + channel activation The Na + channel is activated by the physical impact on the brain tissue in TBI which leads to initiation of action potential and loss of membrane permeability culminating in necrosis and free radical generation (Torre et al., 1973) who first reported the potential therapeutic effect of DMSO in central nervous system injury