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Now, we will mainly discuss changes in gut microbiota in ADs, as well as Clostridium and its metabolites that are responsive to ADs

Leeman et al

However, like all treatments, they can have side effects, particularly if administered improperly or in excessive amounts

PMID: 9018265

In a study [474] where mice were divided into six groups (control, model, 5-ASA, and SCH at varying doses), SCH-treated mice showed substantial weight gain, alleviated colitis severity, decreased inflammatory factors, and improved gut microbiota (GM) composition and bile acid conversion, suggesting SCH's potential as a UC treatment through the regulation of the SGK1/NLRP3 pathway and GM balance

Therefore, EtfD cannot coordinate the fourth iron of a noncubane [4Fe-4S] cluster, and instead uses the cysteine at position 584 to coordinate the third iron and accommodate a linear [3Fe-4S] cluster (Fig