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For patients on long-term semaglutide protocols spanning months or years of treatment , this cumulative deficiency risk is not trivial

and the total score ranges from 0-120

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This immune escape mechanism supports tumor development and maintenance [127]

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Immunostaining for glial fibrillary acidic protein (GFAB, a marker for astrocytes) and ionized calcium-binding adapter molecule 1 (Iba-1, a marker for microglia) indicated reduced astrocyte and microglia activation in both striatum and substantia nigra