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Renal function tests are important, as GLP-1 receptor agonists can occasionally affect kidney function, particularly in patients with pre-existing renal impairment or those experiencing severe gastrointestinal side effects leading to dehydration

Similarly, anyone experiencing unexplained fatigue, weakness, neurological symptoms (such as numbness, tingling or problems with balance), or difficulty losing weight despite appropriate lifestyle measures should consult their GP

8 This effect increased with duration of therapy, and patients had an unclear prophylactic supplementation response

Ann Med 26(6):405-9, 1994

[1] Even so, lyophilized peptides can be hygroscopic